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Proteins give early clue to coronary artery disease

BMJ 2001; 323 doi: (Published 17 November 2001) Cite this as: BMJ 2001;323:1150
  1. Scott Gottlieb
  1. New York

    Levels of blood proteins may help to predict the risk posed by coronary artery disease and help doctors to decide on the best course of treatment.

    Researchers have found that raised levels of myeloperoxidase, an enzyme secreted from activated neutrophils, monocytes, and tissue macrophages, are independently associated with an increased risk of coronary artery disease (JAMA 2001;286:2136-42).

    Dr Stanley Hazen from the Cleveland Clinic Foundation, Ohio, and colleagues collected data for 158 patients with known coronary artery disease and for 175 controls. They measured levels of leucocyte myeloperoxidase and blood myeloperoxidase for each patient. The researchers found …

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