Latent tuberculosis may persist for over 40 years

BMJ 2001; 323 doi: https://doi.org/10.1136/bmj.323.7313.635b (Published 15 September 2001) Cite this as: BMJ 2001;323:635
  1. Anthony O'Regan, assistant professor of medicine (aoregan@lung.bumc.bu.edu),
  2. Martin Joyce-Brady, associate professor of medicine
  1. Pulmonary Center, Section of Pulmonary and Critical Care Medicine, Boston University School of Medicine, Boston, MA 02118, USA

    EDITOR—The recurrence of tuberculous disease emphasises the failure of antimycobacterial treatment based on isoniazid to eradicate latent Mycobacterium tuberculosis infection. We present the follow up of a patient originally reported on in 1953 as a survivor of advanced tuberculous meningitis.1 The original case heralded the remarkable impact of isoniazid in the treatment of tuberculosis.

    The genomes of M …

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