Mutation increases cancer risk in carriers of BRCA2BMJ 2001; 322 doi: https://doi.org/10.1136/bmj.322.7300.1446/a (Published 16 June 2001) Cite this as: BMJ 2001;322:1446
- Judy Siegel-Itzkovich
A single minor mutation in one gene has been the first factor identified as greatly increasing the risk of developing breast cancer at a comparatively young age among women who carry the BRCA2 gene mutation (Proceedings of the National Academy of Sciences 2001;98:3232-6).
The discovery was made by Dr Ephrat Levy-Lahad, a medical genetics researcher at Shaare Zedek Medical Center in Jerusalem, and her colleagues. Dr Levy-Lahad and her team looked at why only some women who carry the BRCA1 and BRCA2 mutations get breast cancer. They studied 257 …