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Human parathyroid hormone may prevent osteoporosis

BMJ 2001; 322 doi: https://doi.org/10.1136/bmj.322.7296.1200/c (Published 19 May 2001) Cite this as: BMJ 2001;322:1200
  1. Scott Gottlieb
  1. New York

    A recombinant human parathyroid hormone significantly reduced the risk of new fractures in postmenopausal women with previous osteoporotic fractures and significantly increased bone density, in a phase III study of the new compound.

    In the trial, researchers randomised 1637 postmenopausal women with previous vertebral fractures to 20 μg or 40 μg of the parathyroid hormone or placebo administered subcutaneously daily. All patients took calcium and vitamin D supplements daily.

    The parathyroid hormone was well tolerated and was associated with about a two thirds reduction in the risk of new spinal fractures and a slightly greater than 50% reduction in the risk of …

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