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Patients with breast cancer can stop tamoxifen after five years

BMJ 2001; 322 doi: http://dx.doi.org/10.1136/bmj.322.7295.1140 (Published 12 May 2001) Cite this as: BMJ 2001;322:1140
  1. Scott Gottlieb
  1. New York

    Women who have had breast cancer gain no benefit from taking tamoxifen for longer than five years, a new study has found.

    The researchers randomly assigned 1172 women who had already taken tamoxifen for five years to continue taking either the drug or a placebo. For seven years after randomisation, a slight advantage was observed in women who discontinued tamoxifen compared with those who continued to receive it (disease-free survival 82% v 78%; P=0.03, …

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