New vaccine against typhoid could eventually be used for babiesBMJ 2001; 322 doi: https://doi.org/10.1136/bmj.322.7294.1084/b (Published 05 May 2001) Cite this as: BMJ 2001;322:1084
- Deborah Josefson
- San Francisco
Researchers from the child health and human development division of the US National Institutes of Health in Bethesda, Maryland, have developed a new vaccine against Salmonella typhi, the bacterium that causes typhoid fever (N Engl J Med 2001;344:1263-9).
An estimated 16-30 million cases of typhoid fever occur annually, resulting in 600 000 deaths. It is spread by the faecal-oral route and is therefore quite common in impoverished areas where sanitation is poor and malnutrition is rampant.
The new vaccine produces a good immune response, is well tolerated, and is effective in protecting young …