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β Blocker response may have gene link

BMJ 2001; 322 doi: http://dx.doi.org/10.1136/bmj.322.7290.814/b (Published 07 April 2001) Cite this as: BMJ 2001;322:814
  1. Scott Gottlieb
  1. New York

    Patients with congestive heart failure and who have a mutation in the angiotensin converting enzyme (ACE) gene are likely to respond especially well to b blockers, a new study has suggested (Circulation 2001;103: 1644-8).

    The current findings relate to people with the mutation known as the ACE deletion (so called because it lacks a small piece of DNA found in the normal ACE gene). Activation of the renin-angiotensin system is known to adversely affect progression of heart failure. Although the ACE …

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