Clinical Review Science commentary

HLA typing

BMJ 2001; 322 doi: https://doi.org/10.1136/bmj.322.7280.218 (Published 27 January 2001) Cite this as: BMJ 2001;322:218
  1. Abi Berger, science editor
  1. BMJ

    Human leucocyte antigens (HLAs) are cell surface molecules found on all nucleated cells. Each individual has a unique set of these antigens, half inherited from each parent, and their typing becomes important before organ transplantation. Typing is also used to identify markers for specific diseases, such as HLA B27, which is known to be closely associated with conditions such as ankylosing spondylitis.

    Two main classes of HLA antigens are recognised: HLA class I and HLA class II. HLA class …

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