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Gene seems to induce metastasis

BMJ 2000; 321 doi: https://doi.org/10.1136/bmj.321.7257.322/c (Published 05 August 2000) Cite this as: BMJ 2000;321:322
  1. Abi Berger
  1. BMJ

    A single gene seems to play a critical part in inducing metastasis in melanoma tumours. Scientists at the Massachusetts Institute of Technology have identified a gene known to be important in regulating the cytoskeleton of cells that seems to control whether a primary melanoma tumour metastasises or not.

    In 90% of all cancers it is secondary tumours that ultimately cause death, so this finding has important implications for future targets for cancer therapy (Nature 2000;406:532-5). Professor Richard Hynes, director of the Center for Cancer Research at the Massachusetts institute, and his colleagues set about looking for clues …

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