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Scientists grow artificial thymus cells

BMJ 2000; 321 doi: https://doi.org/10.1136/bmj.321.7254.136/f (Published 15 July 2000) Cite this as: BMJ 2000;321:136
  1. Abi Berger
  1. BMJ

    Engineers have designed a three dimensional grid that allows stem cells to differentiate into mature T cells ex vivo. The resulting cells are genetically similar to native thymus cells, are fully functional, and may lead to the production of T cells whose reactivity can be directed towards specific foreign antigens, potentially replacing parts of the immune system damaged by disease or chemotherapy (Nature Biotechnology 2000;18:729-34).

    The grid, used by Dr David Scadden, director of experimental haematology, and …

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