Scientists grow artificial thymus cellsBMJ 2000; 321 doi: https://doi.org/10.1136/bmj.321.7254.136/f (Published 15 July 2000) Cite this as: BMJ 2000;321:136
- Abi Berger
Engineers have designed a three dimensional grid that allows stem cells to differentiate into mature T cells ex vivo. The resulting cells are genetically similar to native thymus cells, are fully functional, and may lead to the production of T cells whose reactivity can be directed towards specific foreign antigens, potentially replacing parts of the immune system damaged by disease or chemotherapy (Nature Biotechnology 2000;18:729-34).
The grid, used by Dr David Scadden, director of experimental haematology, and …