Fillers Tribulations of clinical trials

There's more inside the tablet

BMJ 2000; 320 doi: http://dx.doi.org/10.1136/bmj.320.7250.1646 (Published 17 June 2000) Cite this as: BMJ 2000;320:1646
  1. John H Turney, consultant renal physician
  1. Leeds

    Several years ago I was invited to be the medical officer for a geological expedition to the Arctic. The attractions of the beauty and grandeur of the high Arctic in summer are somewhat diminished by swarms of mosquitoes, which are notable for their size and ferocity. Even the locals find the attentions of the cuculid hordes hard to bear, with the caribou preferring to rest on patches of snow, where the lower air temperature discourages the biters. There was at that time unfounded speculation that B vitamins acted as systemic insect repellants,12 possibly because of the aroma of yeast excreted via the sweat. It therefore seemed a good idea to conduct a randomised clinical trial of the effect of …

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