Fillers When I use a word…

Monthly injections

BMJ 2000; 320 doi: https://doi.org/10.1136/bmj.320.7241.1071 (Published 15 April 2000) Cite this as: BMJ 2000;320:1071
  1. Jeff Aronson, clinical pharmacologist
  1. Oxford

    If you want to extend the duration of action of a drug you can give it in a so called modified release formulation, from which it will slowly enter the blood and find its way to the site of action. The modern term modified release was first used, as a blanket term for all such formulations, in 1982, as far as I can discover. And before it came into currency in the 1990s (it was first used in the British National Formulary in the 22nd issue, September 1991), formulations of this kind were described as extended …

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