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Altering a gene in mice prevents obesity

BMJ 2000; 320 doi: https://doi.org/10.1136/bmj.320.7240.962/a (Published 08 April 2000) Cite this as: BMJ 2000;320:962
  1. Scott Gottlieb
  1. New York

    In research that may lead to the development of novel treatments for obesity in humans, scientists have found a single gene in a group of mice that, once altered, allows the animals to eat a glutinous, high fat diet without gaining weight, according to a new study (Nature Genetics 2000;24:377-80).

    In its normal form the gene, called HMGIC, helps mice make more cells to store fat when they have been eating a fatty …

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