Intention to treat analysis is related to methodological quality

doi:10.1136/bmj.320.7240.1007

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Miguel Ruiz-Canela, assistant professor (mcanela@unav.es),
Miguel Angel Martínez-González, acting chair,
Jokin de Irala-Estévez, associate professor

Department of Biomedical Humanities and Department of Epidemiology and Public Health, School of Medicine, University of Navarra, E 31080 Pamplona, Spain
Department of Epidemiology and Public Health, School of Medicine, University of Navarra

EDITOR—In their survey of all randomised controlled trials published in 1997 in four major medical journals, Hollis and Campbell found that only 48% of the reports explicitly mentioned intention to treat analysis.1 In a considerable proportion it was insufficiently described and sometimes inadequately applied. Their results are confirmed by our assessment of all randomised controlled trials published between 1993 and 1995 in the same four journals.2 In addition to our assessment of ethical issues, …