News

PAR2 antagonists—the next generation of anti-inflammatories?

BMJ 2000; 320 doi: https://doi.org/10.1136/bmj.320.7231.334 (Published 05 February 2000) Cite this as: BMJ 2000;320:334
  1. Abi Berger
  1. BMJ

    New understanding of how sensory nerve cells transmit their signals to the central nervous system has been reached by researchers at the University of California in San Francisco.

    Nigel Bunnett, professor of surgery and physiology, and his team have shown that tryptase—a degradatory enzyme known to be involved in triggering the inflammatory process—works by activating a new class of receptor called PAR2 (proteinase activated 2 receptors).

    Professor Bunnett's work suggests that substances that block these receptors could make good candidates for new anti-inflammatory drugs (Nature Medicine 2000;6:151-8).

    When sensory …

    View Full Text

    Sign in

    Log in through your institution

    Free trial

    Register for a free trial to thebmj.com to receive unlimited access to all content on thebmj.com for 14 days.
    Sign up for a free trial

    Subscribe