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COX 2 inhibitors can affect the stomach lining
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BMJ
1999;319:1518.1
- Drugs: CNS (not psychiatric)
- Drugs: musculoskeletal and joint diseases
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- Deborah Josefson
- San Francisco
A new class of analgesics designed to be less ulcerogenic than traditional non-steroidal anti-inflammatory drugs may not protect the gastric lining after all, according to a University of California study (Nature Medicine 1999;5:1415-23, 1348-9).
Their ulcerogenic effect may stem from their antiangiogenic properties, and as such they may be useful anticancer drugs.
The analgesics, agents known as selective cyclo-oxygenase-2 (COX 2) inhibitors, were specifically designed to be less harmful to the gastric mucosal …
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