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Vitamin A analogue protects against breast cancer

BMJ 1999; 319 doi: https://doi.org/10.1136/bmj.319.7220.1312c (Published 13 November 1999) Cite this as: BMJ 1999;319:1312
  1. Janice Hopkins Tanne
  1. New York

    A synthetic vitamin A analogue, fenretinide, reduced the rate of second breast cancers in premenopausal women in a study by Dr Umberto Veronesi of the Istituto Nazionale Tumori and the European Institute of Oncology in Milan and colleagues (Journal of the National Cancer Institute 1999;91:1847-56).

    In postmenopausal women, however, it seemed to increase the risk of a second breast cancer. The drug also reduced the rate of ovarian cancer in women under 50.

    “Chemoprevention is relatively new. The carcinogenic process is multi-step and this substance might interfere with and stop the process,” said Dr Veronesi at a press conference …

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