Cirrhosis mortality and per capita consumption of distilled spirits, United States, 1949-94: trend analysisBMJ 1999; 319 doi: https://doi.org/10.1136/bmj.319.7211.666 (Published 11 September 1999) Cite this as: BMJ 1999;319:666
- Ron Roizen, specialist sociologist (, )
- William C Kerr, assistant research economist,
- Kaye M Fillmore, professor
- University of California, San Francisco, Department of Social and Behavioral Sciences Box 0612, San Francisco, CA 94143-0612, USA
- Correspondence to: R Roizen
- Accepted 2 June 1999
Objective: To describe, evaluate, and suggest interpretations for an observed aggregate level relation between trends in mortality from cirrhosis and per capita consumption of distilled spirits in the United States.
Design: Trend analysis using data on US cirrhosis mortality and per capita alcohol consumption.
Results: There is a consistent long term trend relation between mortality from cirrhosis and per capita consumption of distilled spirits in the United States from 1949 to 1994. Two instances of comparatively sharp drops in the consumption of spirits earlier in the 1940s generated mixed results in predicting changes in cirrhosis mortality.
Conclusions: An aggregate level relation between trends in long term cirrhosis mortality and the consumption of spirits falls considerably short of establishing a direct causal link between the two for individuals. Moreover, two sharp drops in the consumption of spirits generated only mixed results with respect to the short term trend in cirrhosis. Nevertheless, the observed relation between the consumption of spirits and cirrhosis mortality merits further investigation.
US cirrhosis mortality peaked in 1973 but alcohol consumption did not peak until the early 1980s
Both shifts in the distribution of US drinking patterns (which are not reflected in per capita consumption statistics) and the increase in the availability of treatment for alcoholism have been suggested as potential sources of the decline in cirrhosis
The trend in the consumption of distilled spirits from 1949 to 1994 shows a close, aggregate level association with cirrhosis mortality
This aggregate level relation suggests that research is needed into the link between the effects of specific alcoholic beverages and cirrhosis
Funding This work was supported by US National Institute on Alcohol Abuse and Alcoholism grants (No RO1 AA07034 and AA09623) and by a Research Scientist Award (No KO1 AA00073) to KMF.
Competing interests RR received $500 for a consultation unrelated to this research from Anheuser-Busch in 1997.
- Accepted 2 June 1999