Letters

CRASH trial is based on problematic meta-analysis

BMJ 1999; 319 doi: http://dx.doi.org/10.1136/bmj.319.7209.578 (Published 28 August 1999) Cite this as: BMJ 1999;319:578
  1. B Gregson, principal research associate,
  2. N V Todd, consultant anaesthetist, intensive care,
  3. D Crawford, consultant anaesthetist, intensive care,
  4. C J Gerbe, consultant neurosurgeon,
  5. B Fulton, consultant neurosurgeon,
  6. L Taccon, consultant neurosurgeon,
  7. P J Crawford, consultant neurosurgeon,
  8. R P Sengupta, consultant neurosurgeon
  1. Newcastle General Hospital, Acute Services, Newcastle upon Tyne NE4 6BE

    EDITOR—Kmietowicz reports the start of the CRASH trial, a multicentre trial of steroids for treating head injury.1 The meta-analysis which forms the basis for the trial is a good example of how one small study can potentially expose thousands of patients to unnecessary risk. The dose of steroids used in CRASH (2 g methyl prednisolone over 1 …

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