Teaching patients with bipolar disorder to identify early symptoms of relapse

doi:10.1136/bmj.318.7197.1557b

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When were outcomes separated?

Christopher Cates, General practitioner. (chriscates@emailmsn.com)

Manor View Practice, Bushey, Hertfordshire WD2 2NN
University of Manchester Department of Community Psychiatry, Royal Preston Hospital, Preston, Lancashire PR2 9HT

EDITOR—The decision to analyse the relapses for mania and depression separately in Perry et al's trial in patients with bipolar disorder is crucial.1 The reported power analysis was calculated for the overall (mania and depression) relapse rate, but no result is shown relating to the overall relapse rate. This raises the possibility that the decision to split the outcomes was taken later.

The authors …