More studies are needed before giving magnesium sulphate for pre-eclampsiaBMJ 1999; 318 doi: https://doi.org/10.1136/bmj.318.7186.809 (Published 20 March 1999) Cite this as: BMJ 1999;318:809
- Lelia Duley, Obstetric epidemiologist.,
- James Neilson, Professor of obstetrics and gynaecology.,
- Karen Watkins, Clinical research fellow.
- Institute of Health Sciences, Oxford OX3 7LF
- University of Liverpool, Liverpool
- Magpie Trial, Institute of Health Sciences, Oxford
EDITOR—Clark et al argue that magnesium sulphate reduces the risk of eclampsia and should therefore be given to all women with severe pre-eclampsia.1 The study they refer to in support of this view has reported outcome for 685 women out of 822 randomised. A more reliable guide to clinical practice is a systematic review of all relevant trials. Four trials have now compared magnesium sulphate with placebo or no anticonvulsant,2 and the relative …