Letters

Register cannot replace prospective studies in sickle cell disease

BMJ 1999; 318 doi: https://doi.org/10.1136/bmj.318.7184.671a (Published 06 March 1999) Cite this as: BMJ 1999;318:671
  1. A Yardumian, Consultant haematologist,
  2. A Olujohungbe, Senior registrar in haematology,
  3. K Cinkotai, Associate specialist in haematology
  1. North Middlesex Hospital, London N18 1QX
  2. Manchester Royal Infirmary, Manchester M13 9WL

    EDITOR—We welcome the launch of a European register of patients with sickle cell disease treated with hydroxyurea1 and will certainly offer anonymised details of our treated patients. However, Davies and Roberts-Harwood would be the first to agree that a register collecting data retrospectively cannot address research questions in the way that formal prospective controlled studies can.

    We agree that the results of Charache et al's study of hydroxyurea2 were convincing. However, there is wide clinical heterogeneity in this condition, …

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