(Reprinted from BMJ 1948:ii:769-782)

A MEDICAL RESEARCH COUNCIL INVESTIGATION LONDON SATURDAY OCTOBER 30 1948

The following gives the short-term results of a controlled investigation into the effects of streptomycin on one type of pulmonary tuberculosis. The inquiry was planned and directed by the Streptomycin in Tuberculosis Trials Committee, composed of the following members: Dr. Geoffrey Marshall (chairman), Professor J. W. S. Blacklock, Professor C. Cameron, Professor N. B. Capon, Dr. R. Cruickshank, Professor J. H. Gaddum, Dr. F. R. G. Heaf, Professor A. Bradford Hill, Dr. L. E. Houghton, Dr. J. Clifford Hoyle, Professor H. Raistrick, Dr. J. G. Scadding, Professor W. H. Tytler, Professor G. S. Wilson, and Dr. P. D'Arcy Hart (secretary). The centres at which the work was carried out and the specialists in charge of patients and pathological work were as follows:

Brompton Hospital, London.-Clinician: Dr. J. W. Crofton, Streptomycin Registrar (working under the direction of the honorary staff of Brompton Hospital); Pathologists: Dr. J. W. Clegg, Dr. D. A. Mitchison.

Colindale Hospital (L.C.C.), London.-Clinicians: Dr. J. V. Hurford, Dr. B. J. Douglas Smith, Dr. W. E. Snell; Pathologists (Central Public Health Laboratory): Dr. G. B. Forbes, Dr. H. D. Holt.

Harefield Hospital (M.C.C.), Harefield, Middlesex.- Clinicians: Dr. R. H. Brent, Dr. L. E. Houghton; Pathologist: Dr. E. Nassau.

Bangour Hospital, Bangour, West Lothian.-Clinician: Dr. I. D. Ross; Pathologist: Dr. Isabella Purdie.

Killingbeck Hospital and Sanatorium, Leeds.-Clinicians: Dr. W. Santon Gilmour, Dr. A. M. Reevie; Pathologist: Professor J. W. McLeod.

Northern Hospital (L.C.C.), Winchmore Hill, London.-Clinicians: Dr. F. A. Nash, Dr. R. Shoulman; Pathologists: Dr. J. M. Alston, Dr. A. Mohun.

Sully Hospital, Sully, Glam.-Clinicians: Dr. D. M. E. Thomas, Dr. L. R. West; Pathologist: Professor W. H. Tytler.

The clinicians of the centres met periodically as a working …