Genotype linked to long QT syndrome

BMJ 1998; 317 doi: (Published 10 October 1998) Cite this as: BMJ 1998;317:969
  1. Deborah Josefson
  1. San Francisco

    The clinical course of the congenital long QT syndrome, a hereditary arrhythmic disorder, can be predicted through genotypic analysis, according to researchers from the University of Rochester researchers (New England Journal of Medicine, 1998;339:960-5).

    This is the first research that has found a link between variations in genotype and differential clinical disease expression, and the finding may allow doctors to tailor the treatment of patients who have the syndrome according to their genotype.

    The long QT syndrome is caused by defective ventricular repolarisation leading to abnormally long pauses between heart beats. The prolonged pauses can cause …

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