Amyloid clearly implicated in Alzheimer's disease

BMJ 1998; 317 doi: (Published 11 July 1998) Cite this as: BMJ 1998;317:102
  1. Abi Berger, science correspondent
  1. BMJ

    The role of amyloid in Alzheimer's disease looks destined to rise from bit part to lead player with the publication of three papers in the July edition of Nature Medicine. Scientists from three centres have found new evidence that clearly implicates amyloid in the pathogenesis of Alzheimer's disease, as well as having devised a diagnostic test that seems to be fairly specific and created a potential new treatment for the disease.

    One of the reasons that the precise role of fibrillar B amyloid has remained elusive, despite its undeniable presence in the brains of people with Alzheimer's disease, is that none of the experimental mouse models of the disease has exhibited the full range of pathological features found in human Alzheimer's disease. Transgenic mice that express amyloid precursor protein in the cerebral cortex do not seem to sustain neurological pathology, and little neuronal death occurs when rats are injected with quantities of amyloid similar to that found in an amyloid plaque. These findings seemed to show that …

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