Ion channelsBMJ 1998; 317 doi: https://doi.org/10.1136/bmj.317.7150.77 (Published 04 July 1998) Cite this as: BMJ 1998;317:77
Ion specificity of motor end plate acetylcholine receptor
- Jaideep J Pandit, Lecturer in medicine.
- St Hugh's College, Oxford OX2 6LE
- Hammersmith Hospital, London W12 ONN
EDITOR—I was surprised by the assertion of Laniado et al that “acetylcholine…acts at the postsynaptic membrane of the motor end plate to open chloride channels.”1 In a series of classic experiments in the 1960s, Takeuchi and Takeuchi used glass microelectrodes to clamp the end plate region of partially curarised frog sartorius muscle.2 The end plate current decreased …