Approval given for trials of AIDS vaccine

BMJ 1998; 316 doi: (Published 13 June 1998) Cite this as: BMJ 1998;316:1769
  1. Deborah Josefson
  1. San Francisco

    The Food and Drug Administration in the United States has approved final phase clinical trials for the world's first AIDS vaccine.

    The vaccine, known as AIDSVAX, is based on gp120, an HIV envelope glycoprotein that interacts with and binds to T cell surface receptors. It is manufactured by VaxGen, a subsidiary of Genentech.

    The vaccine will be tested on 5000 US volunteers who have tested negative for HIV but are at high risk of contracting AIDS through sexual contact, and on 2500 volunteers from Thailand who are injecting drug users. These …

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