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CF gene may protect against typhoid fever

BMJ 1998; 316 doi: https://doi.org/10.1136/bmj.316.7143.1477j (Published 16 May 1998) Cite this as: BMJ 1998;316:1477
  1. Deborah Josefson
  1. San Francisco

    The gene mutation that causes cystic fibrosis may confer resistance to typhoid fever and to several other infectious agents. The finding may explain why the cystic fibrosis mutation is so prevalent.

    Cystic fibrosis develops in children who inherit two mutant copies of the gene that encodes a protein known as cystic fibrosis transmembrane conductance regulator (CFTR). Abnormal CFTR …

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