Single gene may protect cells against cancer

BMJ 1998; 316 doi: (Published 09 May 1998) Cite this as: BMJ 1998;316:1407
  1. Caroline White
  1. London

    A single gene involved in drug metabolism may protect cells against the development of several cancers. The research was carried out on mice, but the gene has a human equivalent that is widely distributed throughout the body and works in the same way, by producing an enzyme that detoxifies carcinogens (Proceedings of the National Academy of Sciences 1998;95:5275-80).

    Increased concentrations of the enzyme have been reported in many human tumours, including those of the lung, colon, …

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