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Acne drug is linked to severe depression

BMJ 1998; 316 doi: https://doi.org/10.1136/bmj.316.7133.723a (Published 07 March 1998) Cite this as: BMJ 1998;316:723
  1. Deborah Josefson
  1. San Francisco

    The Food and Drug Administration (FDA) in the United States has warned doctors and patients that isotretinoin, a popular treatment for acne, may cause severe depression, psychosis, thoughts of committing suicide, and suicide attempts.

    The warning was generated in response to reports of over 20 incidents of depression and some suicides associated with the …

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