Corticosteroids in acute traumatic brain injuryBMJ 1998; 316 doi: http://dx.doi.org/10.1136/bmj.316.7128.396 (Published 31 January 1998) Cite this as: BMJ 1998;316:396
- David W Newell, Associate professor of neurological surgerya,
- Nancy R Temkin, Associate professor of neurological surgery and biostatisticsa,
- Ross Bullock, Professor of neurosurgeryb,
- Sung Choi, Professor of biostatistics and neurosurgeryb
- a Department of Neurological Surgery, University of Washington, Seattle, WA 98195, USA
- b Division of Neurosurgery, Department of Biostatistics, Medical College of Virginia, Richmond, VA 23298, USA
- c UK Cochrane Centre, NHS R&D Programme, Oxford OX2 7LG
- d Institute of Child Health, University of London, London WC1N 1EH
Editor—The findings of the systematic review of randomised controlled trials of corticosteroids in acute traumatic brain injury1 are in keeping with the conclusions reached by the Committee for Guidelines for the Management of Severe Head Injury, based in the United States. They indicate that the available evidence does not show a benefit of corticosteroids in acute severe traumatic brain injury.2 The guidelines committee therefore recommended that corticosteroids should not be given routinely to patients with severe head injury.
We are puzzled why the authors state that considerable uncertainty remains over the effect of corticosteroids and recommend that a trial requiring 20 000 participants is justified. The meta-analysis showed that the odds ratio for death was 0.91, corresponding to a pooled absolute risk reduction for death in head injured patients treated with steroids of 1.8%, which was far from being significant. Moreover, the subgroup analysis, which analysed trials with only the highest quality of concealment of allocation (blinding), showed that …
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