- Shakeel R Saeed, senior registrar in otolaryngologya
- a University Department of Otolaryngology-Head and Neck Surgery Manchester Royal Infirmary Manchester M13 9WL
Introduction
In 1861 Prosper Ménière described a syndrome characterised by deafness, tinnitus, and episodic vertigo. Contrary to the thinking at that time, he correctly thought that the condition was a disorder of the inner ear.1 In 1938 the principal underlying pathology, endolymphatic hydrops, was described by Hallpike and Cairns (fig 1),2 but the precise aetiology of Ménière's disease still remains elusive. This fact, coupled with the capricious behaviour of the disease and the clinically important response to placebo treatment, has aroused controversy about its management and has plagued the scientific evaluation of the results of the various treatments used.
Histological section of the cochlea showing distension of the scala media (sm) due to endolymphatic hydrops. Note that the basal turn has been spared. Reproduced from Hawke and Jahn3 with permission
Summary points
The aetiology of Ménière's disease is multifactorial but the relation between these factors and the development of the disease remains unknown
Distension of the endolymphatic compartment of the inner ear may be due to otological or systemic disorders and is the constant pathological finding
This condition can be diagnosed on clinical grounds and simple audiometry. Secondary endolymphatic hydrops and space occupying lesions of the cerebellopontine angle need to be excluded
The relapsing-remitting nature of the disorder, response to placebo, and undetermined aetiology have plagued scientific attempts to evaluate treatments
Around three quarters of patients respond to medical treatment or enter a state of prolonged remission. For the rest, surgery aims to control the disabling vertigo
Bilateral Ménière's disease remains a therapeutic challenge
Methods
Over the years, a vast literature has accumulated on Ménière's disease. I have based this article on information gained from three sources.
The first was a Medline search from 1966 to 1997, which yielded nearly 2000 references using the text word “Ménière's” and 546 citations …
Sign in
Article access
Article access for 1 day
Purchase this article for £20 $30 €32*
The PDF version can be downloaded as your personal record







CiteULike
Connotea
Del.icio.us
Digg
Facebook
Mendeley
Reddit
Technorati
Twitter
Stumbleupon
Rapid responses
Latest Responses
Re: Transforming translation
Published 30 May 2012
Re: Bringing Nightingale down to size
Published 29 May 2012
Re: Avoid antimuscarinic drugs in people with dementia
Published 29 May 2012
Re: Strengthening primary health care: Related to the integration of medical training, community service need and health administration
Published 29 May 2012
Re: Strengthening primary health care: Related to the integration of medical training, community service need and health administration
Published 29 May 2012
Most responses
Venous thrombosis in users of non-oral hormonal contraception: follow-up study, Denmark 2001-10 (12 responses)
Published 10 May 2012 - 23:32
The psychiatric oligarchs who medicalise normality (9 responses)
Published 2 May 2012 - 15:42
Are doctors justified in taking industrial action in defence of their pensions? No (8 responses)
Published 8 May 2012 - 12:21
Are doctors justified in taking industrial action in defence of their pensions? Yes (8 responses)
Published 8 May 2012 - 12:21
The hardest thing: admitting error (7 responses)
Published 2 May 2012 - 12:27