Letters

Meta-analysis and the meta-epidemiology of clinical research

BMJ 1998; 316 doi: http://dx.doi.org/10.1136/bmj.316.7127.311b (Published 24 January 1998) Cite this as: BMJ 1998;316:311

Registration of trials should be required by editors and registering agencies

  1. Desmond Julian, Chairmana
  1. a Cardio-Vascular Clinical Trials Forum, Current Science, London W1P 6LB
  2. b Faculty of Medicine, University of Montreal, Montreal, Canada
  3. c Department of Medicine, Faculty of Medicine, University of Montreal

    Editor—Both the editorial by Naylor and the paper by Stern and Simes propose the prospective registration of clinical trials.1 2 Such registration would not only avoid publication bias but also provide the basis for evaluating the final conclusions of trials in the light of the original hypothesis and design.

    It is now possible to register cardiovascular clinical trials on the internet in the Cardio-Vascular Clinical Trials Forum (http://biomednet.com/cvctforum). As Boissel et al and Friedman point out in our introductory issue (soon to be available online in the forum), there are potential difficulties with such registries. This is partly due to the problems of ensuring that trialists do register their trials when the incentive …

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