Effect of calcium supplementation during pregnancy on blood pressure of offspringBMJ 1998; 316 doi: https://doi.org/10.1136/bmj.316.7126.234 (Published 17 January 1998) Cite this as: BMJ 1998;316:234
Authors cannot be sure of effect's generalisability to all children aged 5-9
- Imogen F D Stephens, Senior registrar in public health medicinea
- aArgyll and Clyde Health Board, Paisley PA2 7BN
- bSpecial Programme of Research, Development and Research Training in Human Reproduction, World Health Organisation, 1211 Geneva 27, Switzerland
- cCentro Latinamericano de Perinatologia, Pan-American Health Office/World Health Organisation, Montevideo, Uruguay
Editor-Béliz¡n et al claim to have shown, in a double blind randomised controlled trial, that the systolic blood pressure of children between the ages of 5 and 9 years was lower in those whose mothers had taken calcium during their pregnancy than in those whose mothers had taken placebo.1 Such a finding has epidemiological and public health importance since it may provide the first grade A evidence that intrauterine programming of childhood blood pressure both exists and can be modified by simple nutritional intervention.
While the authors admit that this effect …