Rotavirus vaccine is effective in developing countries

BMJ 1997; 315 doi: (Published 01 November 1997) Cite this as: BMJ 1997;315:1111
  1. Deborah Josefson
  1. San Francisco

    An oral vaccine that has the potential to prevent most life threatening rotavirus infections has been shown to be safe and effective in both developing and developed countries. Concern has been raised, however, that it might be prohibitively expensive for the nations that need it most.

    Infectious diarrhoea is a leading cause of paediatric morbidity and mortality worldwide. There are an estimated 130 million cases of diarrhoea caused by rotavirus each year-18 million of which are classed as severe-resulting in 873000 deaths annually.

    Several studies have shown that a live attenuated vaccine incorporating the four rotavirus serotypes that cause most of the illness in humans is …

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