Concordance of phenprocoumon dose in married couplesBMJ 1997; 315 doi: http://dx.doi.org/10.1136/bmj.315.7108.609 (Published 06 September 1997) Cite this as: BMJ 1997;315:609
Authors did not study patients' diets or compliance
- F Kamali, Lecturer in clinical pharmacologya,
- C Edwards, Senior lecturer in clinical pharmacya,
- H Wynne, Senior lecturera,
- J Cox, Training research fellow in clinical pharmacologya
- a Anticoagulation Research Group, Wolfson Unit of Clinical Pharmacology, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH
- b Utrecht University Hospital, NL 3508 GA Utrecht, Netherlands
Editor—Timon W van Haeften and colleagues examined the influence of diet on the dose of anticoagulant in married couples in whom both spouses were taking phenprocoumon; they also compared the doses taken by these subjects with those taken by subjects matched for age and sex.1 Their results do not justify some of their conclusions.
Although we agree that dietary vitamin K may have an important role in the variability in dose requirements for coumarin drugs, the authors did not provide any details about patients' diets in the study. Married couples living in the same household do not necessarily have similar diets and vitamin K intakes. In any case, other dietary variables may also play a part. For the authors to draw any conclusion about the effect of diet on coumarin requirements, vitamin K concentrations should have been monitored. The …
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