Molecular basis underlying Huntington's chorea foundBMJ 1997; 315 doi: https://doi.org/10.1136/bmj.315.7106.445c (Published 23 August 1997) Cite this as: BMJ 1997;315:445
- Deborah Josefson
- San Francisco
The molecular mechanism underlying several inherited neurodegenerative disorders has been uncovered, a discovery that should lead to new approaches to treatment.
Huntington's chorea and spinocerebellar ataxia type III, two autosomally dominant diseases that lead to late onset dementia and crippling movements, are caused by an abnormal expansion of the DNA trinucleotide sequence cytosine-adenine-guanine (Cell 1997;90:537-8 and Neuron 1997;19:333-44). This sequence codes …