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Sequencing of Helicobacter pylori will radically alter research

BMJ 1997; 315 doi: https://doi.org/10.1136/bmj.315.7105.383 (Published 16 August 1997) Cite this as: BMJ 1997;315:383
  1. Hilary Bower
  1. London

    Publication of the complete genome sequence of the gut pathogen Helicobacter pylori will radically change research approaches and pave the way for completely new methods of treatment, say molecular experts.

    Scientists from the Institute for Genome Research in Rockville, Maryland, United States, have described how H pylori has a circular genome consisting of 1667867 base pairs (Nature 1997;388:539-47). The sequencing offers important clues about how the bacterium, which is the main non-pharmaceutical cause of ulcers, manages to survive and thrive in the hostile acidic environment of the human stomach.

    H pylori is only the seventh bacterium to be completely sequenced. Publication of the sequence places the information in the public domain and ends the simmering …

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