Increased parity and risk of trisomy 21

BMJ 1997; 314 doi: https://doi.org/10.1136/bmj.314.7096.1760a (Published 14 June 1997) Cite this as: BMJ 1997;314:1760

Study measured prevalence of Down's syndrome at birth, not incidence

  1. P O D Pharoah, Heada
  1. a Department of Public Health, University of Liverpool, Whelan Building Quadrangle, Liverpool L69 3GB
  2. b Department of Neonatology, Shaare Zedek Medical Centre, PO Box 3235, Jerusalem, Israel 91031
  3. c Health Division, Israel Central Bureau of Statistics, Jerusalem

    Editor—Michael S Schimmel and colleagues state that the incidence of Down's syndrome is 1.46 per 1000 live births when they mean the prevalence at birth.1 The accompanying commentary claims that the authors used prevalence as a proxy for incidence on the grounds that there were no terminations because the community eschewed prenatal diagnostic services. The authors do not make this claim, …

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