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Gene therapy hope for motor neurone disease

BMJ 1997; 314 doi: https://doi.org/10.1136/bmj.314.7088.1145k (Published 19 April 1997) Cite this as: BMJ 1997;314:1145
  1. Jacqui Wise
  1. BMJ

    A team of French and Danish scientists has shown that gene therapy can slow the gradual destruction of motor neurones in mice.

    The delivery of neurotrophic factors by gene therapy produced a 50% increase in life span, reduced loss of motor axons, and improved neuromuscular function in mice with symptoms of motor neurone disease (Nature Medicine 1997;3:429-36).

    The research, although preliminary, shows that …

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