Coffee drinking and risk of coronary heart diseaseBMJ 1997; 314 doi: https://doi.org/10.1136/bmj.314.7081.680 (Published 01 March 1997) Cite this as: BMJ 1997;314:680
Cholesterol concentrations may have been within natural fluctuations
- M I Gurra
- a Vale View Cottage, Maypole, St Mary's, Isles of Scilly TR21 0NU
- b Department of Human Nutrition, Wageningen Agricultural University, 6703 HD Wageningen, Netherlands
Editor–Rob Urgert and colleagues compared the effects of filtered and cafetiÈre coffee on blood lipid concentrations and found that “After 24 weeks low density lipoprotein cholesterol concentrations were raised by 0.26 (SE 0.11) mmol/l, or 9% over baseline values relative to filtered coffee (P=0.03).”1 I am sceptical about the biological importance of differences with P values of this order; nor can we rule out the possibility that, had the experiment continued for longer, the plasma cholesterol concentration in the cafetiÈre group might have returned to around the baseline value.
During the follow up the plasma cholesterol concentration rose to considerably above the baseline value (5.25 v 4.99 mmol/l) in the group who had previously drunk filtered coffee, although no statistical analyses are presented. The value of 5.25 mmol/l was higher than that in the cafetiÈre group at the end …