Serum cholesterol concentration and postpartum depression

BMJ 1997; 314 doi: https://doi.org/10.1136/bmj.314.7074.143a (Published 11 January 1997) Cite this as: BMJ 1997;314:143

Oestrogen may have been a confounder

  1. Murray Luckas, Research fellowa,
  2. William Buckett, Research fellowa,
  3. Ian Aird, Lecturera,
  4. Charles Kingsland, Consultant gynaecologista
  1. aLiverpool Women's Hospital, Liverpool L8 7SS
  2. b Department of Social Medicine, University of Bristol, Bristol BS8 2PR

    Editor–Barbara Ploeckinger and colleagues use pregnancy and the puerperium as a model for investigating the possible link between falling serum cholesterol concentrations and low mood.1 Although they controlled for progesterone concentrations, which seem to be lower in women with the maternity blues,2 they make no mention of oestrogen concentrations. Oestrogen concentrations fall in the immediate puerperium, and clinical work has shown that oestrogen enhances mood3; indeed, a recent randomised placebo …

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