Effect of deletion polymorphism of angiotensin converting enzyme gene on progression of diabetic nephropathy

BMJ 1996; 313 doi: https://doi.org/10.1136/bmj.313.7071.1554c (Published 14 December 1996) Cite this as: BMJ 1996;313:1554
  1. Michel Marre,
  2. Gilles Chatellier,
  3. Francois Alhenc-Gelas
  1. Professor of therapeutics Medecine B, Centre Hospitalier Universitaire, 49033 Angers, France
  2. Senior registrar Service d'Informatique Medicale, Hopital Broussais, 75014 Paris, France
  3. Director INSERM Unite 367, 75005 Paris

    EDITOR,—Hans-Henrik Parving and colleagues report that patients with diabetic nephropathy who were homozygous for a deletion polymorphism of the angiotensin converting enzyme gene progressed more rapidly towards renal failure than did other diabetic patients with diabetic nephropathy once glycaemic control was controlled for in their analysis.1 This is consistent with the results of a study that we published two years ago2 but contrasts with a previous report from the same group.3

    There are two possible reasons for the discrepancy between …

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