Actual size of increase needs to be measured

doi:10.1136/bmj.313.7066.1209b

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Sally Collins,
Andrew Moore,
Henry McQuay

Research assistant Consultant biochemist Clinical reader in pain relief Pain Relief Unit and Nuffield Department of Anaesthetics, University of Oxford, Oxford Radcliffe Hospital, The Churchill, Oxford OX3 7LJ

EDITOR,—Underlying Anton J M de Craen and colleagues' conclusion that adding codeine 60 mg to paracetamol can result in a small but significant increase in analgesia is the crucial question “How big is small?”1 The benefit of adding 60 mg codeine to paracetamol in studies of single doses can be quantified.2 Thirteen of the 19 reports from de Craen and colleagues' search met our inclusion criteria of comparisons of single doses of oral paracetamol with single doses of …