Failing regimens should be modified with multiple drugs instituted simultaneously

BMJ 1996; 313 doi: https://doi.org/10.1136/bmj.313.7064.1084 (Published 26 October 1996) Cite this as: BMJ 1996;313:1084
  1. J R Greig, Registrar in medical microbiology,
  2. I J Eltringham, Senior registrar in medical microbiology,
  3. K Birthistle, Senior registrar in virology
  1. Public Health Laboratory Services, Department of Medical Microbiology, St George's Hospital Medical School, London SW17 0RE

    EDITOR,—Julia E Clark and Andrew J Cant emphasise the importance of pyrazinamide for mycobacterial killing.1 Though this is pertinent, they do the drug a disservice by adding it alone to a failing treatment regimen.

    The cornerstone of the treatment of Mycobacterium tuberculosis is the use of multiple agents to decrease the number of viable bacteria …

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