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BMJ 1996; 313 doi: (Published 14 September 1996) Cite this as: BMJ 1996;313:0

Holmes on evidenceCommenting on yet another BMJ paper examining a possible relationship between low cholesterol concentration and suicide (p 649) Malcolm Law wonders why there is continued publication of observational studies that fosters the view that uncertainty persists (p 651). After all, the combined results of 13 randomised trials of “statins” suggest that lowering the cholesterol concentration does not increase the risk of death from accidents and suicide. Law quotes Sherlock Holmes's observation that one can have too much evidence: “What was vital was overlaid and hidden by what was irrelevant.” We should, like Holmes, “From …

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