Metabolic effects of hormone replacement preparations

BMJ 1996; 312 doi: https://doi.org/10.1136/bmj.312.7046.1608 (Published 22 June 1996) Cite this as: BMJ 1996;312:1608
  1. Naveed Sattar,
  2. Chris J Packard,
  3. Alan J Jaap
  1. Registrar in clinical chemistry Professor in clinical biochemistry Senior registrar in medicine Glasgow Royal Infirmary, Glasgow G4 0SF

    EDITOR,—The recent article by the Medical Research Council's General Practice Research Framework examined the metabolic effects of an oestrogen only and a combined hormone replacement preparation (containing norgesterol) in women with hysterectomy and concluded that the possibly beneficial and adverse effects of the two regimens were fairly evenly balanced on lipids and coagulability.1 We believe that a greater emphasis should have been placed on the results for high density lipoprotein cholesterol, which is a potent independent risk factor for coronary heart disease in women …

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