Primary biliary cirrhosis: epidemiology helping the clinicianBMJ 1996; 312 doi: http://dx.doi.org/10.1136/bmj.312.7040.1181 (Published 11 May 1996) Cite this as: BMJ 1996;312:1181
- Jane V Metcalf,
- Denise Howel,
- Oliver F W James,
- Raj Bhopal
- The PBC Support Group may be contacted at the British Liver Trust, Central House, Central Avenue, Ransomes Europark, Ipswich IP3 9QG.
- Wellcome research fellow Department of Medicine, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH
- Senior lecturer in statistics Department of Public Health and Epidemiology
- Professor and head Department of Medicine
- Professor and head Department of Public Health and Epidemiology
Epidemiology improves our knowledge of disease
Recent epidemiological and clinical research is changing our thinking on primary biliary cirrhosis, a chronic cholestatic liver disease probably of autoimmune origin. Until the early 1970s primary biliary cirrhosis was perceived as a disease that was rare, presented with persistent jaundice, and usually progressed to death from liver failure.1 Epidemiological and clinical research based on both registers of cases in defined populations and, more commonly, clinical case series has transformed that picture. The disease is much commoner than was believed,2 3 4 as many as half of all patients may have no symptoms of liver disease at diagnosis,5 and both the onset of complications and death can be delayed by treatment with ursodeoxycholic acid6 and, when necessary, liver transplantation. Good clinical and health care strategies will depend on further integration of epidemiological and clinical research to provide better information on the frequency and natural course of the disease and to generate hypotheses about causation.
For both epidemiological and clinical purposes a widely accepted and validated case definition is necessary. In primary biliary cirrhosis the triad of results from liver function tests …