Letters

Trials of adequate size are possible with the right organisation

BMJ 1996; 312 doi: https://doi.org/10.1136/bmj.312.7035.910b (Published 06 April 1996) Cite this as: BMJ 1996;312:910
  1. Peter Brocklehurst,
  2. Diana Elbourne,
  3. Jo Garcia,
  4. Rona McCandlish
  1. Epidemiologist Director, perinatal trials service Social scientist Research midwife National Perinatal Epidemiology Unit, Radcliffe Infirmary, Oxford OX2 6HE

    EDITOR,—Richard J Lilford and colleagues have opened the debate on the difficult problem of clinical trials in rare diseases with insight and clarity.1 We are concerned, however, that some of the messages conveyed in their article may be open to misinterpretation.

    Firstly, readers should not accept that a trial that is not powerful enough to provide a definitive answer is as good (that is, clinically useful) as one that is appropriately sized. There …

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