Letters

Risk of diarrhoea due to Clostridium difficile during cefotaxime treatment

BMJ 1996; 312 doi: https://doi.org/10.1136/bmj.312.7033.778 (Published 23 March 1996) Cite this as: BMJ 1996;312:778

Cefotaxime compares favourably with other third generation cephalosporins

  1. Eugene Rothschild,
  2. Alain Rauss,
  3. Gaby Danan
  1. Head of safety unit for marketed drugs Pharmacoepidemiologist Head of department Corporate Drug Safety and Epidemiology Department, Roussel Uclaf, 102 Route de Noisy, 93235 Romainville, France

    EDITOR,—The retrospective study by M Impallomeni and colleagues shows an increased risk of diarrhoea due to Clostridium difficile in elderly patients receiving cefotaxime.1 The validity of their results is limited by the lack of precise data and by the questionable methodology used.

    Firstly, the authors do not specify the number of cases of C difficile diarrhoea relating to each antibiotic used. Secondly, they do not state the extent to which all cases were correctly identified. Thirdly, exposure to different antibiotics was estimated from …

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